What is Trulicity? How does Trulicity work?

Trulicity

Trulicity injection is indicated as a once-weekly SC injection adjunct to diet and exercise to control glucose levels in adults with diabetes type-2.

Trulicity
Dulaglutide injection

What is trulicity made from?

Dulaglutide is the active ingredient in trulicity injection. Dulaglutide is a GLP-1 agonist, which mimics the natural hormone glucagon. It increases insulin production to control blood sugar levels, so they are easier to manage.

Trulicity doses :

This injection is available as a subcutaneous injection in single-dose pens. Available in strengths of 

  • 0.75mg/0.5mL, 
  • 1.5mg/0.5mL, 
  • 3mg/0.5mL, and 
  • 4.5mg/0.5mL .

You, as the patient, can self-inject a dose once a week in a single short injection. The starting, increasing and maintenance dosage will be determined by your physician only. They are usually starting from low doses and increase month by month.

How to use a trulicity pen:

The pen has a thin needle, and the medicine is injected pretty quickly. It’s less painful than using a syringe, but it’s tricky to use this pen, but it’s simple and easy to get used to. I have made a video about how to use a trulicity pen, please watch that and everything will be clear.

The best injection site:

You can administer by injecting it under the skin in one of the following locations: the abdomen, thigh, or upper arm. You should rotate the injection site weekly. The best injection site is the abdomen but Keep at least 2cm between the injection site and the umbilical cord.

How does trulicity work in the body?

This injection contains Dulaglutide, a hormone that mimics insulin; analog of human glucagonlike peptide-1 (GLP-1) activates the GLP-1 receptor in specific cells to increase insulin secretions in the presence of elevated blood glucose levels. In addition, it delays gastric emptying to decrease postprandial glucose levels. It also lowers glucagon secretion.

What are the side effects:

  • The most common side effect
  • diarrhea, 
  • frequent bowel movements,
  •  nausea, and 
  • retching.

 Other side effects include: 

  • abdominal distress, 
  • abdominal pain,
  •  abdominal tenderness, 
  • asthenia, 
  • dyspepsia,
  •  fatigue, 
  • gastrointestinal pain

How long do trulicity side effects last?

How long do the side effects last & how do you manage the side effects.

Trulicity’s common side effects subside with time, but some last for long and need management. For example, some side effects like lethargy and fatigue may be due to blood sugar levels. Therefore, you should monitor your blood sugar level regularly. In addition, sometimes due to t loss of appetite cause weakness, so you should use some food supplement like omega 3 to overcome that weakness.

Nausea and vomiting will also go away with time. However, if it bothers you, you can take a metoclopramide tablet once or twice per day before a meal. 

For constipation, you can use any herbal product that relieves constipation, and you can also use vegetables in your foods to help ease constipation.

foods to avoid with trulicity:

There are no specific foods to avoid while takingthis injection, but if you have diabetes, experience has shown that high-fat foods will spike your glucose levels.

Foods to avoid while taking trulicity injection include any food that causes your blood sugar to increase. Foods with high-fat levels are also not good for you if you have diabetes, so it is best to avoid them.

Due to the mechanism of dulaglutide, which slows down digestion, it’s better to use vegetables in foods. Protein food like meat and chicken will take time to digest, and you may feel stomach fullness and maybe nauseous, so better to use food like this in a little amount as you are doing dieting.

Trulicity weight loss:

Trulicity is not approved for weight loss, but as I mentioned in the mechanism, it slows down digestion, and you will not feel hungry. So when you don’t feel hungry, you will not eat more food. So the number of calories consumed will be less than the number of calories consumed, and you will be able to lose weight. 

ozempic vs Trulicity:

There are many similarities and differences between Trulicity and Ozempic injections. 

  • The Trulicity and ozempic both are once-weekly injections.
  • Ozempic contain Semaglutide, and Trulicity has Dulaglutide; both are GLP- agonist. It means having the same action.
  • Ozempic weight loss and glycemic control are more than the Trulicity in patients reviews.
  • Ozempic side effects are more worst than Trulicity when I compared the patient’s reviews.
  • Constipation, nausea is more with Ozempic as compared to Trulicty when I asked patients.
  • Ozempic has more glycemic control than Trulicity.
  • Ozempic cost is more than Trulicity cost.

Contraindications

This injection is not recommended in the following conditions,

diabetic retinopathy, which is a kind of eye damage caused by diabetes

low blood sugar

dehydration

diminished kidney function

excessive vomiting

excessive diarrhea

Pancreatitis

medullary thyroid cancer

multiple endocrine neoplasia type 2

C-cell hyperplasia in the thyroid

Family history of medullary thyroid cancer

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